Treatment of Primary Intracranial Germinomas

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Radiologic features of primary intracranial ectopic germinomas

RATIONALE Germinomas are sensitive to radiation therapy and chemotherapy; therefore, correct imaging diagnosis is crucial for them. However, the imaging findings of germinomas originating from off-midline regions displayed different patterns from those originating from midline areas. PATIENT CONCERNS The objective of this study is to describe the radiologic features of primary ectopic germino...

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Primary Intracranial Germinomas: Retrospective Analysis of Five Cases.

AIM Primary intracranial germinomas (PIGs) are rare malignant brain tumors that represent approximately 0.2% to 1.7% of all primary intracranial tumors. PIGs have infrequent, but there is a possibility of spinal cord metastases. In this study, clinical outcomes of five consecutive PIGs have been presented. MATERIAL AND METHODS Medical records were retrospectively reviewed in 1,849 cases of in...

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Granulomatous Response in Intracranial Germinomas: Diagnostic Problems

Intracranial germinomas are rare and account for <0.5% of primary intracranial tumors. In contrast to the gonadal germinomas, these do not show granulomatous response within the tumor. In rare cases, the granulomatous component may obscure the tumor proper and lead to diagnostic difficulties/dilemmas. We report a case of suprasellar germinoma in a 17-year-old boy which showed granulomatous resp...

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Controversies in the management of intracranial germinomas.

Intracranial germinomas are uncommon tumors. In the past, patients have traditionally been diagnosed with a trial of focal radiotherapy without biopsy. If the tumor was radiosensitive, it was presumed to be a germinoma. Because of the minimal morbidity and mortality associated with microsurgical techniques, almost all patients now have a histologic diagnosis and can be treated appropriately. Ra...

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ژورنال

عنوان ژورنال: Neurologia medico-chirurgica

سال: 1987

ISSN: 0470-8105,1349-8029

DOI: 10.2176/nmc.27.841